Description
An NMDA co-agonist; potentiates glutamate-induced currents in oocytes expressing various subunit combinations (EC50s = 0.17-0.32 µM) more potently than glycine; reverses deficits in prepulse inhibition with prepulses of 69 and 73 dB, but not 81 dB, in mice with a mutant form of serine racemase (SrrY269*) at 600 mg/kg; increases the time spent in the target quadrant of the Morris water maze in mice with a mutant form of serine racemase (SrrY269*) at 600 mg/kg; serum levels are decreased in patients with schizophrenia